fbpx

Hyperlipidemia Remains Resolved 12 years Later After Metabolic Surgery

Posted on: 15th Nov, 2020

Before and After Image of Patient from Sasse Surgical

One of the more striking findings we see every week in our long-term follow-up clinic for patients with obesity, type 2 diabetes, and past metabolic surgery is the profound drop in triglycerides after metabolic surgery.

While elevated LDL cholesterol commonly falls over the years following metabolic surgery, the abrupt drop in triglycerides is swift and more profound. Both sleeve gastrectomy and Roux en Y gastric bypass create changes in the hormonal biochemistry of the body that result in improved lipid profile and metabolic function. While several bioactive peptides are implicated, the precise mechanism of the lipid improvements remains undetermined. Hormones GLP-1 and PYY are increased after sleeve and gastric bypass, and hormones ghrelin and leptin are reduced, perhaps offering a trail for researchers to follow, to explain lipid effects through a gut-intestine-liver-brain mechanism. We know that triglycerides fall especially reliably in animal models of sleeve and bypass, independent of weight effects, just as occurs in humans.

These findings are illustrated in a New England Journal of Medicine study that examined 1,156 patients including control groups of patients who did not undergo metabolic surgery. 12 years later, all metabolic parameters favored the metabolic surgery group, and most striking is the near complete resolution of hypertriglyceridemia.

 

Interestingly, the profound reduction in triglycerides likely adds to the factors of CV risk reduction from bariatric surgery, namely lowering LDL-C, blood pressure and Hgba1c in reducing cardiovascular risks.

Today, metabolic surgery consists of a 45-minute procedure with 4 or 5 Band-aids and a safety record better than that of appendectomy, hysterectomy or hernia repair.

Similar Recent Posts

  • How Does Metabolic Surgery Work?

    • sasse-surgical-how-metabolic-surgery-works

      There are a lot of misconceptions about weight-loss surgery, from what the procedure itself actually involves to recovery times to its long-term effects. If you’re researching how metabolic surgery works, keep reading. From Then… Seventy-five years ago, weight-loss surgery started to get a bit of traction as surgeons began more safely altering the stomach and Read More…

  • Weight-Loss Surgery for Seniors – Advised or Too Late? | A Post on Sixty & Me

    • sasse-surgical-weight-loss-surgery-for-seniors

      At one time, weight-loss surgery was largely considered a cosmetic procedure. But times have changed, and the more appropriately named “metabolic surgery” has proven to be not only effective, but safe. That’s true for seniors as well. In a recent post for Sixty & Me, Dr. Sasse explains whether weight-loss surgery for seniors is advised, Read More…

  • Can Bladder Leakage be Fixed?

    • sasse-surgical-can-bladder-leakage-be-fixed

      Bladder leakage is an astonishingly common problem. It stems from dysfunction of the complex pelvic floor muscles and can diminish control of both the bladder and the bowels over time. It is a more severe problem than many people realize, interfering with sleep, hygiene, and the ability to simply go participate and enjoy life. But Read More…

Address
Sasse Surgical Associates
75 Pringle Way
Suite 804

Reno, NV 89502
Minimally invasive weight loss surgery experts.info@sassesurgical.com(775) 829-7999
Phone
Office Hours
Monday
7:30 am - 5:00 pm
Tuesday
7:30 am - 5:00 pm
Wednesday
7:30 am - 5:00 pm
Thursday
7:30 am - 5:00 pm
Friday
7:30 am - 3:00 pm
Saturday
Closed
Sunday
Closed